These results, together with a past report showing that a small-molecule ACKR3 agonist CCX771 exhibits anxiolytic-like actions in mice,2 help the concept of targeting ACKR3 as a novel solution to modulate the opioid system, which could open up new therapeutic avenues for opioid-associated Diseases. Disclaimer: The above is actually https://robertj715lso1.wikikali.com/user