There's a release of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors inside the dorsal horn to reduce afferent pain transmission and deliver analgesia. Consequently, medication like clonidine that concentrate on alpha-two receptors can influence the transmission of pain. This doc doesn't comprise all feasible interactions. https://mixbookmark.com/story5343803/considerations-to-know-about-onolidine